Possible use of acoustic nonlinearity of a substance for generation of the second harmonic of sound in a controllable sample, that can be a living organism or other self-organizing system, is considered. The proposed method of control over the state of the self-organizing system is based on the assumption that it contains a system of giant electric dipoles whose states are governed by a self-organizing mechanism or metabolic pumping. The control is reduced to a change of the parameters of the system itself.