Vol. 38, issue 01, article # 5

Abstract:

Community-acquired pneumonia is among the most common acute infectious diseases. According to official statistics, pneumonia accounted for up to 50% of respiratory-disease mortality in the Russian Federation in 2005–2017. Ground-level ozone, being a key component of urban smog, is one of little-studied risks of community-acquired pneumonia. This work studies the effect of ground-level ozone on the rate of community-acquired pneumonia among Moscow residents in the warm season over a five-year period (2006–2009 and 2011). The study results have enabled us to conclude that ground-level ozone contributes to an increase in the community-acquired pneumonia rate among Moscow residents in summer. Daily average concentrations of ground-level ozone of 60–80 mg/m³ can increase the community-acquired pneumonia rate by 30% compared to low-ozone periods, especially in combination with unfavorable weather conditions, such as high air temperature and low humidity. The results will help human ecologists and health care professionals to make the urban air safer.

Keywords:

O3, ground-level ozone, air pollution, health, morbidity, community-acquired pneumonia

References:

1. State of Global Air Report 2024. URL: https://www.stateofglobalair.org/resources/report/state-global-air-report-2024 (last access: 03.09.2024).
2. Global'nye rekomendatsii VOZ po kachestvu vozdukha: kasayushchiesya tverdykh chastits (TCh_2,5 i TCh₁₀), ozona, dvuokisi azota, dvuokisi sery i okisi ugleroda. Rezyume. VOZ, 2021. https://iris.who.int/bitstream/handle/10665/345334/9789240035409-rus.pdf.
3. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 22 december 2017 year N 165 Ob utverzhdenii gigienicheskikh normativov GN 2.1.6.3492-17 «Predel'no dopustimye kontsentratsii (PDK) zagryaznyayushchikh veshchestv v atmosfernom vozdukhe gorodskikh i sel'skikh poselenii». URL: https://docs.cntd.ru/document/556185926.
4. Postanovlenie Glavnogo gosudarstvennogo sanitarnogo vracha RF ot 28 january 2021 year N 2 Ob utverzhdenii sanitarnykh pravil i norm SanPiN 1.2.3685-21 «Gigienicheskie normativy i trebovaniya k obespecheniyu bezopasnosti i (ili) bezvrednosti dlya cheloveka faktorov sredy obitaniya». URL: https://docs.cntd.ru/document/573500115#6540IN.
5. Niu Y., Yang T., Gu X., Chen R., Meng X., Xu J., Yang L., Zhao J., Zhang X., Bai C., Kang J., Ran P., Shen H., Wen F., Huang K., Chen Y., Sun T., Shan G., Lin Y., Wu S., Zhu J., Wang R., Shi Z., Xu Y., Ye X., Song Y., Wang Q., Zhou Y., Ding L., Yang T., Yao W., Guo Y., Xiao F., Lu Y., Peng X., Zhang B., Xiao D., Wang Z., Zhang H., Bu X., Zhang X., An L., Zhang S., Cao Z., Zhan Q., Yang Y., Liang L., Cao B., Dai H., Wu T., He J., Li H., Kan H., Wang C. Long-term ozone exposure and small airway dysfunction: The China pulmonary health (CPH) study // Am. J. Respir. Crit. Care. Med. 2022. V. 205, N 4. P. 450–458. DOI: 10.1164/rccm.202107-1599OC.
6. Albright M., Guttenberg M.A., Tighe R.M. Ozone-induced models of airway hyperreactivity and epithelial injury // Methods Mol. Biol. 2022. V. 2506. P. 67–81. DOI: 10.1007/978-1-0716-2364-0_5.
7. Hargreave F.E., Dolovich J., O'Byrne P.M., Ramsdale E.H., Daniel E.E. The origin of airway hyperresponsiveness // J. Allergy. Clin. Immunol. 1986. V. 78, N 5. P. 825–32. DOI: 10.1016/0091-6749(86)90226-5.
8. Aris R.M., Christian D., Hearne P.Q., Kerr K., Finkbeiner W.E., Balmes J.R. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy // Am. Rev. Respir. Dis. 1993. V. 148, N 5. P. 1363–1372. DOI: 10.1164/ajrccm/148.5.1363.
9. Atkinson C.E., Kesic M.J., Hernandez M.L. Ozone in the development of pediatric asthma and atopic disease // Immunol. Allergy. Clin. North. Am. 2022. V. 42, N 4. P. 701–713. DOI: 10.1016/j.iac.2022.06.001.
10. Fang X., Huang S., Zhu Y., Lei J., Xu Y., Niu Y., Chen R. Short-term exposure to ozone and asthma exacerbation in adults: A longitudinal study in China // Front. Public. Health. 2023. V. 10. P. 1070231. DOI: 10.3389/fpubh.2022.1070231.
11. Mallia P., Johnston S.L. Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations // Proc. Am. Thorac. Soc. 2005. V. 2, N 4. P. 361–372. DOI: 10.1513/pats.200504-025SR. PMID: 16267363.
12. Evstaf'eva E.V., Lapchenko V.A., Makarova A.S., Burukhina T.F., Abibulaeva N.K., Evstaf'eva I.A. Otsenka dinamiki kontsentratsii prizemnogo ozona i meteorologicheskikh parametrov kak faktorov riska vozniknoveniya neotlozhnykh sostoyanii zdorov'ya naseleniya // Himicheskaya fizika. 2019. V. 38, N 11. P. 42–51.
13. Mikerov A.N. Faktory, uchastvuyushchie v modulirovanii mekhanizmov immunnoi zashchity legkikh pri pnevmonii // Immunologiya, patogenez. 2012. Iss. 111. P. 81–83.
14. Stepanov E.V., Andreev V.V., Chuprov D.V., Ivashkin V.T. Korrelyatsiya chastoty zarazhenii i smertnosti ot COVID-19 s anomal'no vysokim soderzhaniem ozona v prizemnoi atmosfere Moskvy letom 2021 year // Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2022. V. 32, N 3. P. 18–22.
15. Krivosheev V.V., Stolyarov A.I., Semenov A.A. Vliyanie ozona na zabolevaemost' i smertnost' naseleniya Evropy v period tret'ei volny pandemii COVID-19 // Obshchestvennoe zdorov'e i zdravookhranenie. 2021. N 472. P. 5–11.
16. Avdeev S.N., Dekhnich A.V., Zaitsev A.A., Kozlov R.S., Rachina S.A., Rudnov V.A., Sinopal'nikov A.I., Tyurin I.E., Fesenko O.V., Chuchalin A.G. Vnebol'nichnaya pnevmoniya: federal'nye klinicheskie rekomendatsii po diagnostike i lecheniyu // Pul'monologiya. 2022. V. 32, N 3. P. 295–355. DOI: 10.18093/0869-0189-2022-32-3-295-355.
17. Adaptirovano iz ofitsial'nykh dannykh Federal'noi sluzhby gosudarstvennoi statistiki (ROSSTAT). URL: https://rosstat.gov.ru/ (data obrashcheniya: 03.09.2024).
18. Bilichenko T.N., Bystritskaya E.V., Chuchalin A.G., Belevskii A.S., Batyn S.Z. Bilichenko T.N., Bystritskaya E.V., Chuchalin A.G., Belevskii A.S., Batyn S.Z. Smertnost' ot boleznei organov dykhaniya v 2014–2015 years i puti ee snizheniya. 2016. V. 26, N 4. P. 389–397. DOI: 10.18093/0869-0189-2016-26-4-389-397.
19. Torres A., Peetermans W.E., Viegi G., Blasi F. Risk factors for community-acquired pneumonia in adults in Europe: A literature review // Thorax. 2013. V. 68, N 11. P. 1057–1065. DOI: 10.1136/thoraxjnl-2013-204282. PMID: 24130229; PMCID: PMC3812874.
20. Muthumbi E., Lowe B.S., Muyodi C., Getambu E., Gleeson F., Scott J.A.G. Risk factors for community-acquired pneumonia among adults in Kenya: A case-control study // Pneumonia (Nathan). 2017. V. 9, N 17. DOI: 10.1186/s41479-017-0041-2.
21. Almirall J., Blanquer J., Bello S. Community-acquired pneumonia among smokers // Arch. Bronconeumol. 2014. V. 50, N 6. P. 250–254. DOI: 10.1016/j.arbres.2013.11.016.
22. Guo C., Yu T., Lin C., Chang L.Y., Bo Y., Wong M.C.S., Tam T., Lau A.K.H., Lao X.Q. Habitual exercise, air pollution, and pneumonia mortality: A longitudinal cohort study of approximately 0.4 million adults // Am. J. Epidemiol. 2022. V. 191, N 10. P. 1732–1741. DOI: 10.1093/aje/kwac113. PMID: 35773998.
23. Wang H.T., Zhang H., Xue F.Z., Zhao L., Cao W.C. Associations of air pollutants with pneumonia hospital admissions in Qingdao, China: A prospective cohort study // Environ. Sci. Pollut. Res. Int. 2022. V. 29, N 19. P. 27779–27787. DOI: 10.1007/s11356-021-17892-7.
24. Li R., Jiang N., Liu Q., Huang J., Guo X., Liu F., Gao Z. Impact of air pollutants on outpatient visits for acute respiratory outcomes // Int. J. Environ. Res. Public. Health. 2017. V. 14, N 1. P. 47. DOI: 10.3390/ijerph14010047.
25. Mikerov A.N., Alekseeva N.I., Abramkina S.S., Eliseev Yu.Yu. Rol' surfaktantnogo belka A i ego okisleniya v chuvstvitel'nosti k eksperimental'noi pnevmonii // Izv. Samarskogo nauchnogo tsentra Rossiiskoi akademii nauk. 2010. V. 12, N 1–7. P. 1769–1773.
26. Kotel'nikov S.N., Stepanov E.V. Vliyanie prizemnogo ozona na zdorov'e naseleniya // RAN. Trudy instituta obshchei fiziki im. A.M. Prokhorova. 2015. V. 71. P. 72–94.
27. Gosudarstvennoe prirodookhrannoe byudzhetnoe uchrezhdenie «Mosekomonitoring». URL: https://mosecom.mos.ru/ (data obrashcheniya: 03.09.2024).
28. Stantsiya skoroi i neotlozhnoi meditsinskoi pomoshchi im. A.S. Puchkova Departamenta zdravookhraneniya g. Moskvy. URL: https://mos03.ru/ (data obrashcheniya: 03.09.2024).
29. Vserossiiskii nauchno-issledovatel'skii institut gidrometeorologicheskoi informatsii – Mirovoi tsentr dannykh. URL: http://aisori-m.meteo.ru/waisori/index0.xhtml (data obrashcheniya: 03.09.2024).
30. Zhang Y., Li J., Wu C., Xiao Y., Wang X., Wang Y., Chen L., Ren L., Wang J. Impacts of environmental factors on the aetiological diagnosis and disease severity of community-acquired pneumonia in China: A multicentre, hospital-based, observational study // Epidemiol. Infect. 2024. V. 152, N 80. DOI: 10.1017/S0950268824000700.
31. Trubitsyn A.V., Kotel'nikov S.N. Issledovanie korrelyatsionnykh vremennykh svyazei kontsentratsii prizemnogo ozona i zdorov'ya naseleniya v tsentral'nykh regionakh Rossii // Vestn. MGTU MIREA. 2015. N 1. P. 235–242.
32. Cherednichenko A.V., Cherednichenko Aleks.V., Cherednichenko V.S., Nysanbaeva A.S. Vremennaya dinamika prizemnogo ozona i ee vliyanie na zabolevaemost' v krupnykh gorodakh Kazakhstana // Gidrometeorologiya i obrazovanie. 2021. N 1. P. 29–49.
33. Antokhin P.N., Antokhina O.Yu., Antonovich V.V., Arshinova V.G., Arshinov M.Yu., Belan B.D., Belan S.B., Davydov D.K., Dudorova N.V., Ivlev G.A., Kozlov A.V., Pestunov D.A., Rasskazchikova T.M., Savkin D.E., Simonenkov D.V., Sklyadneva T.K., Tolmachev G.N., Fofonov A.V. Vzaimosvyaz' dinamiki gazovogo sostava i meteorologicheskikh velichin v raione Tomska // Optika atmosf. i okeana. 2020. V. 33, N 7. P. 529–537. DOI: 10.15372/AOO20200705; Antokhin P.N., Antokhina O.Yu., Antonovich V.V., Arshinova V.G., Arshinov M.Yu., Belan B.D., Belan S.B., Davydov D.K., Dudorova N.V., Ivlev G.A., Kozlov A.V., Pestunov D.A., Rasskazchikova T.M., Savkin D.E., Simonenkov D.V., Sklyadneva T.K., Tolmachev G.N., Fofonov A.V. Interrelation between dynamics of gas composition and meteorological parameters in the region of Tomsk // Atmos. Ocean. Opt. 2020. V. 33, N 6. P. 629–637.
34. Stepanov E.V., Andreev V.V., Konoval'tseva L.V., Kasoev S.G. Prizemnyi ozon v atmosfere Moskvy vo vremya pandemii COVID-19 // Optika atmosf. i okeana. 2022. V. 35, N 8. P. 655–663. DOI: 10.15372/AOO20220809; Stepanov E.V., Andreev V.V., Konovaltseva L.V., Kasoev S.G. Surface ozone in the atmosphere of Moscow during the COVID-19 pandemic // Atmos. Ocean. Opt. 2022. V. 35, N 6. P. 732–740.
35. Zvyagintsev A.M., Kuznetsova I.N., Shalygina I.Yu., Lapchenko V.A., Brusova N.E., Arkhangelskaya A.A., Tereb N.V., Lezina E.A. Prichiny i faktory polozhitel'nykh anomalii prizemnoi kontsentratsii ozona v Moskovskom regione i na yugo-vostochnom poberezh'e Kryma // Optika atmosf. i okeana. 2016. V. 29, N 6. P. 493–502. DOI: 10.15372/AOO20160608; Zvyagintsev A.M., Kuznetsova I.N., Shalygina I.Yu., Lapchenko V.A., Brusova N.E., Arkhangelskaya A.A., Tereb N.V., Lezina E.A. Causes and factors of positive surface ozone anomalies in the Moscow Region and on the southeastern coast of the Crimea // Atmos. Ocean. Opt. 2016. V. 29, N 5. P. 551–560.
36. Belan B.D., Sklyadneva T.K. Troposfernyi ozon. 4. Fotokhimicheskoe obrazovanie troposfernogo ozona: rol' solnechnoi radiatsii // Optika atmosf. i okeana. 2008. V. 21, N 10. P. 858–868.
37. Rybakov D.S., Belashev B.Z. Pogodnye faktory i vyzovy skoroi meditsinskoi pomoshchi po povodu boleznei organov dykhaniya v gorode Petrozavodske // Ekologiya cheloveka. 2021. N 6. P. 36–48.